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KMID : 0371320000590010077
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Journal of the Korean Surgical Society
2000 Volume.59 No. 1 p.77 ~ p.83
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Expression of Vascular Endothelial Growth Factor (VEGF) and p53 in Colorectal Cancer
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홍성우/Seong Woo Hong
이현철/강윤경/나양원/장석효/백인욱/이혁상/Hyunchul Lee/Yun Kyung Kang/Yang Won Nah/Surk Hyo Chang/In Wook Paik/Hyucksang Lee
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Abstract
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Purpose: Neovascularization has been shown to be essential for the growth of solid tumors. Vascular endothelial growth factor (VEGF) is one of the most important mediators of angiogenesis, and recent studies have demonstrated that the p53 tumor
suppressor gene plays an important role in controlling tumor angiogenesis. We examined the expression of VEGF and p53 as a function of microvessel density to evaluate its clinical significance in colorectal cancer and to investigate the
correlation
of
VEGF and p53. Methods: The study material included 20 patients who survived more than 5 years postoperatively without distant metastasis (non-metastasis group) and 21 patients who had synchronous (10 patients) and metachronous (11 patients)
metastasis
(metastasis group). Immunohistochemical staining for VEGF, p53 protein and factor VIII-related antigen was done. Results: The expression rate of VEGF was 20% in non-metastatic tumors and 71% in metastatic tumors (p＜0.05). The VEGF expression was
not
correlated with microvessel density. Otherwise, the microvessel density were 32.9?9.1 in non-metastatic tumors and 40.1?12.0 in metastatic tumors (p＜0.05). VEGF expression was correlated with p53 over expression. Conclusion: VEGF expression
might
be a
useful prognostic factor for metastasis in colorectal cancer. Also, our findings suggest the presence of a p53-VEGF pathway in colorectal cancer.
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KEYWORD
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